With the standard 2200 and mono coils, if the ground you are working is variable, then you will most likely have a difficult time as you will be forever re-balancing the detector and questioning if it is a target or another ground noise. Also in some really hot areas, you might not even be able to ground balance the coil all the way to the ground.
If the ground is mild/uniform, the a mono coil will give really good depth and be very usable.
It's all about using the correct tool for the job.
If you want sensitivity to small gold, you will need a small coil and the ground you are working needs to be shallow. The severity of that ground will determine if you can use a mono coil.
On the flip side, if you are searching for bigger deep nuggets, you need a big coil, the ground will be deeper so there won't be the smaller bits right near the surface anyway.
If you want great sensitivity and depth all in one coil, buy a GPZ.
Cheers Mick